I know it is really hard to go back when you know how rough it will make you feel-I tried to look at as a bad dose of flu( a normal person problem)No one would expect you to get out of bed with flu. The U.S. Food and Drug Administration originally approved the drug in 1996. I stayed on top of my medicine, I rinsed my mouth with salt water to prevent mouth sores and all that. The content on this site is for informational purposes only. I found it helped a great deal so I do hope you get to enjoy yours. I don't know about AC, but when I was on TC, I was told that it's not cumulative, so I would not be feeling worse as chemo progressed.Good luck to Donna, I hope she gets the rest she needs. Hope you are all enjoying the sunshine and feeling better. Doctors may lower the dose or prescribe drugs that reduce the risk of allergic reactions to deal with these types of side effects. Exercise can help combat fatigue; a simple daily walk with a friend can help. I was initially told to have the chemo in the hope they could conserve the breast! Men who are treated with this medication should use effective birth control during and for 4 months after the last dose. That's really great that she had that positive response though, seems worth it and hopeful for the rest of us! I ended up in hospital with spiked temperature, although nothing showing in my bloods, but tremendous discomfort and feeling very unwell. Paracetamol Ibuprofen/codiene didn't work. I had 4 months neojuvent you all, besides the sea swimming, crafting, reading and writing poetry, I have taken up cycling result of the biopsy by the end of this week. The median overall survival (OS) was 81 months . That was on the dose dense A/C. At that time, TAXOTERE was typically used for advanced prostate cancer, after all other treatments had failed. If youre considering taking Taxotere to treat your cancer, you need to be prepared for what might come. They started to put another chemical, I dont know what it was, into my infusion bag so that it would help but I still was nauseous and diarrhea would start that day. Stay strong honey xxxxxxxxxxx, Thank you Lainey66, I will give Kin gingival a try as I feel I am in a vicious circle of mouth problems making eating difficult and tablets which need to be taken with food. They get worse with each cycle. xx, I'm with you on this I was the same didn't think I could go on but you do, I'm all done & back to work & back to normal (as normal as can be) good luck keep strong , Thank you for sharing your experience it help me know that it can be done. OR. Best wishes Jules xxx. Good luck , The first dose of docetaxol was the worst for me. TAXOTERE was first approved for the F.D.A. In addition, dietary changes may help. Some common Taxotere side effects include: Heres what cancer patients had to say about their experiences with Taxotere: I started chemotherapy. I had to be hospitalized twice due to intractable nausea, vomiting and diarrhea. So I am sorry to confirm what you already know - the Taxotere is s*** and much more agressive than the FEC but you will get to the end of it. But I am in good health and loving life. Signs of a reaction can include: feeling hot or flushed shivering itching a skin rash feeling dizzy a headache feeling breathless or wheezy swelling of your face or mouth pain in your back, tummy or chest. Hello there, Two weeks to recover! an infection was never found, though. Worst effect in Cycle 2 and 3 was in lack of taste and the awful chemical tast in my mouth at all times. and Friday, Donna did too much on Saturday, taking my daughter to the mall; shopping for most of the day. My reaction to Taxol was different. You should let your doctor or nurse know if you experience any shortness of breath, difficulty breathing, or pain in your chest. Try to get up and about rather than stay in bed - it was better for me to keep as active as I could and just didn't do anything at all on the really low days. I started on Tamoxifen and switched to Anastrozole after a year, which I'll be taking for 10 years. You could talk to your doctor about your concerns and see if they can give you a lower dose if necessary?They also have pills for most things-I was told that they could probably help with everything but the tiredness. Stick with it. You won't be up to doing anything. Most people notice that their neuropathy gets better 2 to 4 months after chemotherapy, but it can take up to 1 year to fully go away. None worked. Get the B**tard out for good! I'm just shellshocked by it all but I'm glad I was just finished my full treatment for breast cancer after 10 years. I think I am coming to the end of feeling like I have hit by a bus with the chronic aches in all my joints and bones. The pain is horrendous and for me it moves from anywhere to anywhere. You may also need to take your temperature at home during your treatment to stay on top of fevers. I still have a mountain to climb with surgery and radio therapy but it can't be any worse than this. Drugmakers developed it from the bark of the Pacific Yew tree, and researchers sometimes refer to it as a plant alkaloid. I had them for for all 3 Fec. If docetaxel does not work or stops working, cabazitaxel (Jevtana) may . Talk to your oncology care team so they can prescribe medications to help you manage nausea and vomiting. If you ask about people's favourite CPAP machine, you can find those who love an APAP instead. Shari S. (Breast Cancer, Invasive Ductal Carcinoma (IDC),Triple Positive, Stage 4). Avoid things that may worsen the symptoms, such as heavy or greasy/fatty, spicy or acidic foods (lemons, tomatoes, oranges). Your nurse will check you for signs of a reaction during your treatment. In the larger STAMPEDE trial (2962 patients), adding docetaxel to standard hormonal therapy significantly improved survival among men with newly diagnosed, hormone-nave advanced prostate cancer. Remember, not all advice works for everyone. You may also feel irritable, dizzy, or short of breath. Hard to rest with all the side effects of all the drugs but I did my best. 1. Cancer treatment can affect your appetite and, in some cases, the side effects of treatment can make eating difficult. Need to get myself prepared for the next one. Knowing How to Handle Your Worst Days on Taxotere. Your oncology care team can recommend medications to relieve diarrhea. You may wear nail polish, but not fake nails. But as I say.. We're now closer to the end.. 2 more to go.. Then an operation for me And immunotherapy for a year but chemo and op are the big ones to get over.. You'll get through it.. And there is life after chemo. It helps with pain so uncomfortable in spasms but endurable if I dont climb too many stairs with lead legs, It may have helped the mouth too, the stronger dose did make me reach for the bonjella where moments before was ok. 10 days of horrible tastes and softer foods has been hard. Furthermore, the overall response rate for docetaxel in the intent-to-treat population (42.5%) is superior to the response rate of either doxorubicin as second-line therapy . If this were to happen, the only fix is an invasive surgery. Grapefruit can change how your body absorbs this medication. pathology report has our Onc ordering additional scans. Taxotere is a mitotic inhibitor that interferes with your bodys cell division process. Keep reading to learn more about what to expect on your worst days on Taxotere. There is a risk that this medication may leak out of the vein at the injection site, resulting in tissue damage that can be severe. . 10 year old is self sufficient. I am sorry that she is not feeling well. You will be given a corticosteroid prior to the infusion to prevent severe fluid retention and allergic reactions. Overall I did find the T harder than Fec but others say they found it the other way around so it's just pot luck really. - currently getting pumped of the lovely docetaxel! It is very frustrating when you just want to get on with life but he was advised to 'listen to what his body was saying and act accordingly' on an hour to hour basis if necessary. Suffering stomach cramps today probably due to upset stomach and not eating right. I'm taking Codeine and paracetamol with little effect. It was tough going, but I got there. At least week three is getting close, mine starts next Tuesday. Can eat, not been sick, not taken antisickness meds, but nausia with ukky taste but poor sleep got worse. I had my first Taxotere on Monday and am not coping at all. Brady appears to be expanding his brand rapidly in 2023. Try riding it out my friend and know that at the end you will be glad you did. Future - Worst Day (Official Audio) - YouTube 0:00 / 3:06 Future - Worst Day (Official Audio) Future 12.5M subscribers Subscribe 2.5M views 1 year ago #Future #WorstDay Future - Worst. I never threw up really, but I had underlying nausea all the time. She did have both extremes of the intestinal issues. In 2022 . It had to have been that I just did too much. Any one have experience with getting 2019 with breast cancer ER negative HER2 positive and positive nodes. If you do not have a bowel movement for 2-3 days, you should contact your healthcare team for suggestions to relieve constipation. While it sounds harmless enough, constantly tearing eyes can cause other health issues. Sun sensitivity can last even after chemotherapy is completed. I've had all three FEC sessions and coped really well and was positive and active. I finished T & C on April 1 (total of 6 treatments). The one time I threw up was after my second round. Take care. I have a good support system at home who do just about everything as I have been bed or sofa bound for the last 10 days with just small walks around the house to keep the circulation going. xx. Give yourself a great big pat on the back, you are nearly there!!! I would go to work when I was able to and just did what I could. Have had one cycle of that and have the second next week. Carry on being her strength and pass on my love to her xx. Call your oncology care team if you are unable to keep fluids down for more than 12 hours or if you feel lightheaded or dizzy at any time. The effects from the chemo were still the typical things though. These Taxotere side effects are less common, meaning they occur in 10-29 percent of patients receiving Taxotere: Vomiting Muscle/bone/joint pain (myalgias and arthralgias) Low platelet count (This can increase your risk of bleeding) Increases in blood tests measuring liver function. Docetaxel interferes with the function of microtubules, resulting in inactive microtubule bundles, causing cells to die. Many people lose alltheir body hair, including their eyebrows and eyelashes. July 16, 2018. It is not a substitute for professional medical advice. Try saltines, or ginger ale to lessen symptoms. Your story kinda reads similar to my wife's when she was on Docetaxel. Thanks everyone for your messages of support. As I have not had much of an appetite due to mouth issues, I had constipation but once that passed I have had loose bowels. fatigue. I just had my first Docetaxal dose over a week ago.. Have you rang your chemo hotline? Dragged myself to picc line clean at hospital.bad mistake, will have district nurse call next time. Taxotere is part of a family of drugs known as taxanes that work by preventing cell growth. Copyright 2000-2022 Cancer Survivors Network. On 9-1-09, I finished 6 cycles of Taxotere, Carboplatin and Herceptin. Many women who receive taxane -based chemotherapy to treat breast cancer experience long-term peripheral neuropathy, according to follow-up data from a large clinical trial. You may experience a metallic taste or find that food has no taste at all. I was neutropenic with infection and just thought it was after effects of chemo. If we can get through this we can face anything. Looking forward to a semi normal diet and tea again in a few days with a settled stomach. Ps Voltarol Gel is good rubbed in for the lower back pain. Each day from now I knowI will get stronger and begin to do small task.Tthe feeling when I went for the last Chemo was a good I walked out and thought great I made it through now to get throught he effects. Does anyone have any suggestions of anything that can help me .. Still on the journey. xx, No problem you keep strong & you will get through it, I've never cried so much in my life I think it was my way of dealing with it. Your healthcare provider can recommend medications and other strategies to help relieve pain. Hope you are well now too. *Qualifying persons may obtain medications directly from patient assistance programs without any out-of-pocket cost (or for less than $49 per medication). Copyright @ 2019 binews.org | All Right Reserved. Like many have stated, I was OK for the two days following and then felt like sh*t for two or three days and then was on the mend and better until the next treatment. Cannot speak personally here other than as the wife of a hubby who had chemo at the end of 2012 and was equally 'lousy' with all the side effects. Gone too far now to stop just need to finish the course. . This may vary depending on whether the number of blood cells has returned to normal between each cycle. So close to week three now, exercise nil, so bored with all the sofa days. An analysis of several studies found that chemotherapy regimens that include an anthracycline are better than a regimen that doesn't include an anthracycline for women diagnosed with early-stage, HER2-negative breast cancer with a high risk of recurrence. Receive the latest resources and updates in your inbox. Despite all this discomfort, I'm staying positive - I know these are the worst days, and I should begin feeling better any time now. Your hair may become thin, brittle, or may fall out. Let your oncology care team know if you have any excess bruising or bleeding, including nose bleeds, bleeding gums or blood in your urine or stool. APAP vs. CPAP: Whats the Best Machine for Sleep Apnea? It was a one-and-a-half-hour dose. If mouth sores become painful, your doctor or nurse can recommend a pain reliever. Keep reading our blogs for morehealth blogs to help you live a healthy life. Meanwhile just keep in mind that you are going through this because you want to live and enjoy your family. Eating a healthy diet helps you deal with side effects and fight infections. Any comments, please. I had chemo every 3wks on 3meds for 6 months, so the week before i had to go back was when I was feeling my best. I don't think you have "gone wrong" anywhere, more that T has hit you hard and you would like to be in a better place for the next 2. You'll get there too. The end is now in sight and just keep thinking what a good job the chemo is doing getting rid of this nasty disease. Severe symptoms are less common but require dose modifications. A stool softener once or twice a day may prevent constipation. Scared to the point of not being able to sleep properly. (2013) demonstrated that nano-formulation improved plasma PK and tumor delivery of Doc compared to the unprocessed Doc. It is a combination of two chemotherapy medicines: Docetaxel (Taxotere) Cyclophosphamide (Cytoxan) Docetaxel is a type of chemotherapy medicine called an taxane. Please. Try some meditation (use an app if you don't have any). It might also be worth checking things like iron levals-you can adjust you diet or get pills to help with that. It can be given alone or with other drugs. Last reply: 8 years ago. Thank you for taking the time to send me such an inspirational account of your experience, reading it almost made me cry but it hit in all the right places to make me fight this and get on with the treatment. Effective birth control is necessary during treatment and for 2 months after treatmentfor women. Around that time I had violent throw up for a couple of sessions, and then that was it. 4. Avoid any food that you think smells or tastes bad. My doctors have been very good and have assured me that they caught it early. Docetaxel is a microtubule inhibitor used to slow cell growth. The Docetaxel/Taxotere is the drug causing this nasty side effect. Even when carefully and correctly administered by trained personnel, this drug may cause a feeling of burning and pain. It may get worse after you have your last chemotherapy treatment. My diet is so bland in taste no matter what I try, if the mouth problem resolves and I can enjoy a varied diet maybe my stomach will settle better. Docetaxel is its generic name, and it belongs to the taxane class of drugs. Do not apply anything to the site unless instructed by your care team. TAXOTERE is sterile, non-pyrogenic, and is available in single-dose vials containing 20 mg (0.5 mL) or 80 mg (2 mL) docetaxel (anhydrous). These symptoms can last for several months or longer after treatment ends. I have anti nausea meds that work its just the new chemo is a lot stronger. If you notice any changes in how you feel during the infusion, let your nurse know immediately. Men initially treated with Taxotere had favorable outcomes compared to those who were initially treated with Novantrone: Median overall survival was 22 months for men treated with Taxotere first and 15 months for those treated with Novantrone first. Basically I'm at my lowest and need positive boost. In its mechanism of action, Taxotere prevents the inner structures of cancer cells from building, which stops cell division and eventually leads to cancer cell death. Common reported side effects of Taxotere (docetaxel) include: Injection site pain or swelling Temporary hair loss Nausea Vomiting Diarrhea Constipation Loss of appetite Fingernail or toenail changes Take care. I have other family and friends help but they have their own lives that need to go on. I have a soup maker so maybe I should give it a go. I spent a week in hospital after the 3rd Taxotere + radiotherapy. I had four rounds of Herceptin, Carboplatin, and Taxotere. If you are not eating enough, nutritional supplements may help. You should preferably avoid the regular consumption of grapefruits and grapefruit juice while taking DOCEtaxel. Keep the thoughts positive. Hope we get a good July and August to compensate for the months we missed on the sofa. It was just the drugs working their way through my system. While it sounds harmless enough, constantly tearing eyes can cause other health issues. Talk to your healthcare team for helpful tips on dealing with this side effect. The dose or prescribe drugs that reduce the risk of allergic reactions to deal with these types of side include. Wife 's when she was on docetaxel temperature, although nothing showing in my bloods, nausia. Can change how your body absorbs this medication should use effective birth control during and for 2 months treatmentfor! A healthy life i 'm just shellshocked by it all but i got there on 1. 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